More than 60% of all Amazon sales come from independent sellers. But the mechanics of selling on Amazon profitably in 2026 look meaningfully different — FBA fees restructured January 15, 3.5% fuel surcharge added April 17, aged inventory surcharges starting 90 days earlier. This complete guide covers account setup, 2026 fee structure, product research, listing optimisation with Amazon’s AI tools, advertising, and Brand Registry — with every step linked to official Amazon documentation.